Poly(lactic-co-glycolic acid)s (PLGA) is a biodegradable polymer, and its degradation is a chemical process involving the scission of the polymer backbone and the formation of monomers and oligomers. In this process, the number of terminal carboxyl groups continues to increase, and the degradation rate is accelerated, resulting in the phenomenon of degradation autocatalysis, resulting in a decrease in relative molecular weight, the formation of water-soluble fragments, and further hydrolysis into biocompatible endogenous monomers Lactic and glycolic acids, which are eventually metabolized into energy, carbon dioxide, and water. https://www.cd-bioparticles.ne....t/polylactic-co-glyc
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